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Methotrexate interferes with certain enzymes which play a role in immune system function.

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Tumor necrosis factor antagonists — Tumor necrosis factor antagonists are medications that were originally designed for treatment of rheumatoid arthritis. In the absence of tetracycline or analogs thereof, wild-type levels of transcription of the target gene operatively linked to the tet operator sequence(s) occur.

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Lipid-associated preparations have previously been considered primarily for patients who are intolerant of or have an infection refractory to the deoxycholate preparation.

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